Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/1677-5449.007917
Jornal Vascular Brasileiro
Review Article

Associação de variantes polimórficas com síndrome metabólica: uma revisão integrativa

An integrative review of associations between polymorphic variants and the metabolic syndrome

Jamille Silva Oliveira, Rita Narriman Silva de Oliveira Boery

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Resumo

A patogênese da síndrome metabólica, ou seja, de cada um de seus componentes, é complexa e não totalmente elucidada. Por isso, há grande dificuldade em se estabelecer uma definição de quais fatores clínicos e biológicos seriam os principais determinantes no seu desenvolvimento. Esta revisão tem como objetivo caracterizar a produção científica brasileira que aborda o estudo da síndrome metabólica associada aos fatores genéticos. Foram incluídos 15 estudos, levando em consideração os critérios de inclusão e exclusão. Nossa análise revela uma razoável quantidade de trabalhos brasileiros que investigam a relação de genes e suas variantes polimórficas com a síndrome metabólica e seus fatores de risco. Dessa forma, ressalta-se a necessidade de mais trabalhos que examinem melhor o papel biológico ou a relação dos polimorfismos genéticos em pacientes com síndrome metabólica ou com seus fatores de risco.

Palavras-chave

polimorfismo genético; síndrome metabólica; hipertensão; obesidade; resistência à insulina; dislipidemia

Abstract

The pathogenesis of metabolic syndrome, i.e. of each of its components, is complex and has not been entirely elucidated. As a result, it is very difficult to establish a definition of which clinical factors are the most important determinants of its development. The objective of this review is to describe Brazilian scientific research investigating associations between the metabolic syndrome and genetic factors. We selected fifteen studies that met the inclusion and exclusion criteria. Our analysis revealed that there is a modest volume of Brazilian studies investigating relationships between genes, their polymorphic variants and the metabolic syndrome and its risk factors. Therefore, more studies are needed to better understand the biological roles played by genetic polymorphisms and their relationships with metabolic syndrome or its risk factors.

Keywords

genetic polymorphism; metabolic syndrome; hypertension; obesity; insulin resistance; dyslipidemias

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