Jornal Vascular Brasileiro
Jornal Vascular Brasileiro
Review Article

Terapia gênica de isquemia de membro é uma realidade?

Is gene therapy for limb ischemia a reality?

Sang Won Han; Carlos Alberto Vergani Junior; Paulo Eduardo Ocke Reis

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Resumo: O conceito de terapia angiogênica surgiu no início da década de 90, o que pode ser feito com genes que codificam fatores de crescimento para promover a formação de novos vasos e o remodelamento de vasos colaterais. Como o procedimento dessa terapia geralmente consiste em apenas injeções locais de vetores, esse processo é pouco invasivo, rápido e de simples realização. Entretanto, desde as primeiras evidências clínicas do efeito de terapia gênica com o fator de crescimento de endotélio vascular (vascular endothelial growth factor, VEGF) vistos nos pacientes com doença arterial obstrutiva periférica até hoje, apenas dois fármacos de terapia angiogênica foram aprovados, um na Rússia e outro no Japão, o que parece um número muito pequeno diante do grande número de investimentos feitos por meio de estudos pré-clínicos e clínicos. Afinal, podemos considerar que a terapia angiogênica já é uma realidade?


terapia gênica, aterosclerose, doença arterial periférica, isquemia de membro


The concept of angiogenic therapy emerged in the early 1990s. The method employs genes that encode growth
factors to promote formation of new vessels and remodeling of collateral vessels. Since the procedure involved in
this therapy usually only consists of local injections of vectors, the process is minimally invasive, quick, and simple
to perform. However, since the first clinical evidence of the effects of gene therapy with vascular endothelial growth
factor (VEGF) was observed in patients with peripheral artery disease, to date only two angiogenic therapy drugs
have been approved, one in Russia and another in Japan, which seem a very small number, in view of the large volume
of investment made in pre-clinical and clinical studies. After all, can we conclude that angiogenic therapy is a reality? 


gene therapy; atherosclerosis; peripheral artery disease; limb ischemia.


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