Jornal Vascular Brasileiro
Jornal Vascular Brasileiro
Letter to the Editor

Venous thromboembolism in women: new challenges for an old disease

Tromboembolismo venoso em mulheres: novos desafios para uma velha doença

Alvin Oliver Payus; Constance Liew Sat Lin; Azliza Ibrahim; Norlaila Mustafa

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Dear Editor,

We read with great interest the article by Oliveira AL et al., entitled “Venous Thromboembolism in Women: New Challenges for An Old Disease,” which was recently published in volume 19, July 2020.1 Firstly, we would like to praise the authors for their effort in summarizing the associations between venous thromboembolism (VTE) and clinical situations peculiar to women in the comprehensive non-systematic review. The authors have written the review in great detail and have outlined an exhaustive list of possible links between VTE and woman in various clinical condition, especially during pregnancy or while taking hormonal treatment such as the oral contraceptive pill and hormonal replacement therapy. However, as readers, we believe it would be of great benefit if additional information could be included, such as the treatment of established pulmonary embolism in pregnant women and a recommended algorithm for diagnosing VTE in pregnant women. Apart from that, in addition to the risk factors mentioned in the review, which include smoking, obesity, and positive family history of VTE, we believe that previous history of trauma, especially to the chest, is also a significant risk factor2 which can lead to pulmonary embolism that arises de novo3 and warrants inclusion in the review. Nevertheless, we agree with the authors that VTE in women is a major clinical challenge in modern medical practice and believe that this comprehensive review is beneficial and can be used for future reference, especially in implementing guidelines and protocols to improve the quality of life of women needing care.


1 Oliveira AL, Paschôa AF, Marques MA. Tromboembolismo venoso na mulher: novos desafios para uma velha doença. J Vasc Bras. 2020;19:e20190148.

2 Payus AO, Rajah R, Febriany DC, Mustafa N. Pulmonary embolism masquerading as severe pneumonia: a case report. Open Access Maced J Med Sci. 2019;7(3):396-9. PMid:30834009.

3 Van Gent JM, Zander AL, Olson EJ, et al. Pulmonary embolism without deep venous thrombosis: de novo or missed deep venous thrombosis? J Trauma Acute Care Surg. 2014;76(5):1270-4. PMid:24747459.

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