Jornal Vascular Brasileiro
Jornal Vascular Brasileiro
Original Article

Evaluation of seasonal and monthly variation and location of deep vein thrombosis

Avaliação da variação sazonal e mensal e da localização da trombose venosa profunda

Serkan Burç Deşer; Berk Arapi

Downloads: 0
Views: 121


Background: Deep vein thrombosis of the lower extremities is associated with a significant burden of comorbidities.

Objectives: In this study, our objective was to investigate the presence of seasonal variation in deep vein thrombosis (DVT) and assess the location of the thrombus.

Methods: Out of 8177 patients admitted to two university hospitals and referred to outpatient clinics, we included a total of 611 consecutive patients (316 females, 295 males) diagnosed with acute deep vein thrombosis in this retrospective study. The mean age of the patients was 59.35±18.49 years, ranging from 1 to 96 years. Patients were categorized into four groups by age.

Results: DVT was found to be more frequent in the summer (n = 190 or 31%, p = 0.003) and specifically in August (n = 65 or 10.6%, p = 0.014), while it was least frequent in the spring (n = 128 or 20.9%) and in May (n = 40 or 6.5%). However, when comparing seasons, no significant differences were observed in terms of seasonal variation (p = 0.062) or monthly variation (p = 0.143).

Conclusions: Contrary to previous studies, this study demonstrated a higher occurrence of DVT during the summer, particularly in August. However, it did not reveal a clear seasonal pattern. One plausible explanation for these findings could be the adverse winter conditions and transportation challenges within the province, which may result in fewer DVT patients being able to reach hospitals for timely treatment.


deep vein thrombosis, seasonal variation, risk factors


Contexto: A trombose venosa profunda (TVP) dos membros inferiores está associada a uma carga significativa de comorbidades.

Objetivos: Investigar a presença de variação sazonal na TVP e identificar a localização do trombo.

Métodos: Dos 8.177 pacientes internados em dois hospitais universitários e encaminhados para ambulatórios, incluímos um total de 611 pacientes consecutivos (316 mulheres, 295 homens) diagnosticados com TVP aguda neste estudo retrospectivo. A idade média dos pacientes foi de 59,35±18,49 anos, variando de 1 a 96 anos. Os pacientes foram categorizados em quatro grupos com base na idade.

Resultados: A TVP foi mais frequente no verão (n = 190 ou 31%, p = 0,003), especificamente em agosto (n = 65 ou 10,6%, p = 0,014), e menos frequente na primavera (n = 128 ou 20,9%) e em maio (n = 40 ou 6,5%). No entanto, ao comparar as estações, não foram observadas diferenças significativas em termos de variação sazonal (p = 0,062) e variação mensal (p = 0,143).

Conclusões: Ao contrário de estudos anteriores, este estudo demonstrou maior ocorrência de TVP no verão, principalmente em agosto. No entanto, não revelou um padrão sazonal claro. Explicações plausíveis para essas descobertas seriam as condições adversas do inverno e dificuldades de deslocamento, o que pode resultar em menos pacientes com TVP chegando aos hospitais para tratamento oportuno.


trombose venosa profunda; variação sazonal; fatores de risco


1 Ribeiro DD, Bucciarelli P, Braekkan SK, et al. Seasonal variation of venous thrombosis: a consecutive case series within studies from Leiden, Milan and Tromsø. J Thromb Haemost. 2012;10(8):1704-7. PMid:22681473.

2 Christensen AL, Dethlefsen C, Severinsen MT, Kristensen SR. Seasonal variation of venous thrombosis: a consecutive case series within studies from Leiden, Milan and Tromsø: a rebuttal. J Thromb Haemost. 2013;11(3):568-70. PMid:23279121.

3 Dentali F, Ageno W, Rancan E, et al. Seasonal and monthly variability in the incidence of venous thromboembolism: a systematic review and a meta-analysis of the literature. Thromb Haemost. 2011;106(3):439-47. PMid:21725580.

4 Stubbs MJ, Mouyis M, Thomas M. Deep vein thrombosis. BMJ. 2018;360:k351. PMid:29472180.

5 Zöller B, Li X, Ohlsson H, Sundquist J, Sundquist K. Age, and sex specific seasonal variation of venous thromboembolism in patients with and without family history: a nationwide family study in Sweden. Thromb Haemost. 2013;110(6):1164-71. PMid:24048360.

6 Hong J, Lee JH, Lee JY, et al. Prominent seasonal variation in pulmonary embolism than deep vein thrombosis incidence: a Korean venous thrombosis epidemiology study. Korean J Intern Med. 2020;35(3):682-91. PMid:31640336.

7 Fink AM, Mayer W, Steiner A. Seasonal variations of deep vein thrombosis and its influence on the location of the thrombus. Thromb Res. 2002;106(2):97-100. PMid:12182906.

8 Jorde R, Haug E, Figenschau Y, Hansen JB. Serum levels of vitamin D and haemostatic factors in healthy subjects: the Tromso study. Acta Haematol. 2007;117(2):91-7. PMid:17135721.

9 Brown HK, Simpson AJ, Murchison JT. The influence of meteorological variables on the development of deep venous thrombosis. Thromb Haemost. 2009;102(4):676-82. PMid:19806252.

10 Damnjanović Z, Jovanovic M, Ilic N, et al. Seasonal variations in the incidence of idiopathic lower extremity deep vein thrombosis on the territory of South Serbia. HealthMED. 2012;6:2477-81.

11 Montes Santiago J, Rey García G, Mediero Domínguez A. Seasonal changes in morbimortality caused by pulmonary thromboembolism in Galicia. An Med Interna. 2003;20(9):457-60. PMid:14755899.

12 Manfredini R, Imberti D, Gallerani M, et al. Seasonal variation in the occurrence of venous thromboembolism: data from the MASTER registry. Clin Appl Thromb Hemost. 2009;15(3):309-15. PMid:18544594.

13 Jang MJ, Kim HJ, Bang SM, et al. Seasonal variation in the occurrence of venous thromboembolism: a report from the Korean Venous Thromboembolism Working Party. Thromb Res. 2012;130(4):e199-202. PMid:22901545.

14 Zhao H, Li Y, Wu M, et al. Seasonal variation in the frequency of venous thromboembolism: an updated result of a meta-analysis and systemic review. Phlebology. 2020;35(7):480-94. PMid:32036737.

15 Masotti L, Ceccarelli E, Forconi S, Cappelli R. Seasonal variations of pulmonary embolism in hospitalized patients. Respir Med. 2005;99(11):1469-73. PMid:15894476.

16 Lee AYY, Levine MN. Venous thromboembolism and cancer: risks and outcomes. Circulation. 2003;107(23, Suppl. 1):I17 -21. PMid:12814981.

17 Damnjanović Z, Jovanovic M, Sarac M, Stepanovic N, Lazarevic M, Milic D. Correlation between climatic and biochemical parameters in etiopathogenesis of unprovoked deep vein thrombosis of the lower limbs. Phlebology. 2021;36(5):407-13. PMid:33251939.

18 Lan Chang C, Shipley M, Marmot M, Poulter N. Lower ambient temperature was associated with an increased risk of hospitalization for stroke and acute myocardial infarction in young women. J Clin Epidemiol. 2004;57(7):749-57. PMid:15358404.

19 Damnjanović Z, Jovanovic M, Stojanovic M. Correlation between the climatic factors and the pathogenesis of deep vein thrombosis. Hippokratia. 2013;17(3):203-6. PMid:24470728.

Submitted date:

Accepted date:

Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)"> Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)">
65257261a953953b16792df3 jvb Articles
Links & Downloads

J Vasc Bras

Share this page
Page Sections