Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/1677-5449.202500101
Jornal Vascular Brasileiro
Original Article

Impacto da temperatura na produção de espuma densa de polidocanol a 1%: comparação entre as técnicas de Tessari e seringa dupla em estudo experimental

Impact of temperature on the production of 1% polidocanol foam: comparison between the Tessari and double-syringe techniques in an experimental study

Genaro Fahrnholz Buonsante; Marcos Arêas Marques; Bernardo Cunha Senra Barros; Verônica Cunha Assunção; Stênio Karlos Alvim Fiorelli; Rossano Kepler Alvim Fiorelli

http://dx.doi.org/10.1590/1677-5449.202500101 J Vasc Bras, vol.24, e20250010, 2025
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Resumo

Contexto: A espuma densa de polidocanol é amplamente utilizada na escleroterapia para o tratamento de varizes de membros inferiores, sendo influenciada por diversas variáveis nos métodos de preparo e pela temperatura ambiente.

Objetivos: Comparar a influência da temperatura na meia-vida e no diâmetro das bolhas na espuma densa de polidocanol a 1% utilizando as técnicas de Tessari e da seringa dupla.

Métodos: O estudo utilizou espuma densa de polidocanol a 1%, preparada em temperatura ambiente e resfriada a 4 °C, por meio de duas técnicas: técnica de Tessari e técnica da seringa dupla. A meia-vida em segundos da espuma densa foi avaliada registrando-se o tempo necessário para a drenagem de metade do volume líquido, e o diâmetro das bolhas foi analisado por microscopia. As diferenças entre os grupos foram consideradas significativas quando p ≤ 0,05.

Resultados: O resfriamento aumentou significativamente a meia-vida da espuma densa, especialmente quando a técnica da seringa dupla foi utilizada. A técnica de Tessari produziu bolhas menores em ambas as condições de temperatura.

Conclusões: O resfriamento do conjunto de polidocanol a 1% + ar ambiente gerou aumento da meia-vida, independentemente da técnica de preparo utilizada. Não houve influência da temperatura no diâmetro das bolhas.

Palavras-chave

 escleroterapia; varizes; polidocanol; temperatura; insuficiência venosa; eficácia

Abstract

Background: Polidocanol (POL) foam is widely used in sclerotherapy for the treatment of lower limb varicose veins and its properties are influenced by multiple variables, including preparation methods and room temperature.

Objectives: To compare the influence of temperature on the half-life and bubble diameter of 1% polidocanol foam using the Tessari and double syringe techniques.

Methods: The study employed 1% polidocanol foam prepared at room temperature and cooled to 4 °C, using two techniques: the Tessari technique and the double syringe technique. The foam half-life was recorded, defined as the time in seconds taken for half of the liquid volume to drain. Bubble diameter was analyzed with microscopy. Differences between groups were considered significant at p ≤ 0.05.

Results: Cooling significantly extended the half-life of the foam, especially when the double syringe technique was employed. The Tessari technique produced smaller bubbles under both temperature conditions.

Conclusions: Cooling the mixture of 1% polidocanol and room air increased half-life, irrespective of the preparation technique employed. Temperature had no effect on bubble diameter.

Keywords

sclerotherapy; varicose veins; polidocanol; temperature; venous insufficiency; efficacy

References

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Submitted date:
01/27/2025

Accepted date:
05/07/2025

Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)"> Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)">
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