Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/1677-5449.202501811
Jornal Vascular Brasileiro
Artigo Original

Risco de complicações em cirurgia vascular: desenvolvimento de modelo clínico preditivo

Risk of complications in vascular surgery: development of a clinical predictive model

Juliana Peres; Jeferson Freitas Toregeani; Ana Julia Vendrametto

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Resumo

Contexto: Complicações pós-operatórias em cirurgia vascular estão associadas a elevada morbimortalidade e custos hospitalares, exigindo ferramentas preditivas confiáveis para estratificação de risco.

Objetivos: Desenvolver e validar um modelo clínico para estimar o risco de complicações pós-operatórias em cirurgia vascular.

Métodos: Estudo retrospectivo com 510 doentes submetidos a cirurgias vasculares entre 2021 e 2024, divididos em subgrupos arteriais, venosos e de acesso vascular. Variáveis clínicas e cirúrgicas foram analisadas por regressão logística multivariada, e o desempenho avaliado por meio da curva ROC.

Resultados: A taxa global de complicações foi de 17,6%, sendo maior nos procedimentos arteriais (35,6%) do que nos venosos (11,3%) e de acesso vascular (6,9%). Na amostra total, idade (odds ratio [OR] 1,03; p = 0,006), injúria renal crônica (OR 9,94; p < 0,001), tabagismo (OR 3,29; p = 0,001) e tempo de procedimento (p = 0,038) foram preditores independentes, enquanto o uso contínuo de anticoagulantes teve efeito protetor (OR 0,39; p = 0,036). Nos modelos específicos, diabetes melito tipo 2 (OR 13,54; p < 0,001) e injúria renal crônica (OR 15,30; p = 0,007) foram determinantes no grupo venoso; o tabagismo associou-se ao risco no grupo de acesso vascular (OR 9,57; p = 0,081); e a injúria renal crônica manteve significância no grupo arterial (OR 6,50; p < 0,001). O modelo demonstrou bom desempenho discriminativo (área sob a curva ROC [AUC] total = 0,806).

Conclusões: O modelo proposto mostrou boa acurácia e aplicabilidade clínica, permitindo estratificação de risco individualizada em diferentes contextos da cirurgia vascular. A validação externa é necessária para confirmar sua utilidade.

Palavras-chave

 cirurgia vascular; complicações pós-operatórias; avaliação de risco

Abstract

Background: Postoperative complications in vascular surgery are associated with high morbidity, mortality, and hospital costs, highlighting the need for reliable predictive tools for risk stratification.

Objectives:To develop and validate a clinical model to estimate the risk of postoperative complications in vascular surgery.

Methods: This retrospective study included 510 patients who underwent vascular surgeries between 2021 and 2024, divided into arterial, venous, and vascular access subgroups. Clinical and surgical variables were analyzed using multivariate logistic regression, and model performance was evaluated using the receiver operating characteristic curve.

Resultados: The overall complication rate was 17.6%, being higher in arterial procedures (35.6%) than venous procedures (11.3%) or vascular access surgeries (6.9%). In the total sample, age (odds ratio [OR] 1.03; p = 0.006), chronic kidney disease (OR 9.94; p < 0.001), smoking (OR 3.29; p = 0.001), and procedure time (p = 0.038) were independent predictors, while chronic anticoagulant use had a protective effect (OR 0.39; p = 0.036). In the specific subgroup models, type 2 diabetes mellitus (OR 13.54; p < 0.001) and chronic kidney disease (OR 15.30; p = 0.007) were significant predictors in the venous access group, smoking was associated with risk in the vascular access group (OR 9.57; p = 0.081), and chronic kidney disease was significant in the arterial group (OR 6.50; p < 0.001). The model showed good discriminatory performance (overall area under the curve [AUC] = 0.806).

Conclusions: The proposed model demonstrated good accuracy and clinical applicability, allowing individualized risk stratification across different vascular surgery contexts. External validation is needed to confirm its usefulness.

Keywords

vascular surgery; postoperative complications; risk assessment

Referências

1 Kristensen SD, Knuuti J, Saraste A, et al. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur Heart J. 2014;35(35):2383-431. https://doi.org/10.1093/eurheartj/ehu282. PMid:25086026.

2 Devereaux PJ, Sessler DI. Cardiac complications in patients undergoing major noncardiac surgery. N Engl J Med. 2015;373(23):2258-69. https://doi.org/10.1056/NEJMra1502824. PMid:26630144.

3 Tsialtas D, Bolognesi MG, Tecchio T, Azzarone M, Quaini F, Bolognesi R. Clinical, electrocardiographic and echocardiographic features in patients with major arterial vascular disease assigned to surgical revascularization. Vasa. 2014;43(6):443-9. https://doi.org/10.1024/0301-1526/a000391. PMid:25339162.

4 Tsialtas D, Bolognesi MG, Volpi R, Bolognesi R. Atherosclerotic vascular diseases have really the same risk factors? Comparison between large abdominal aortic aneurysm and obstructive non-coronary arterial disease. Vascular. 2017;25(6):629-34. https://doi.org/10.1177/1708538117708474. PMid:28509621.

5 Poldermans D, Hoeks SE, Feringa HH. Pre-operative risk assessment and risk reduction before surgery. J Am Coll Cardiol. 2008;51(20):1913-24. https://doi.org/10.1016/j.jacc.2008.03.005. PMid:18482658.

6 Nowygrod R, Egorova N, Greco G, et al. Trends, complications, and mortality in peripheral vascular surgery. J Vasc Surg. 2006;43(2):205-16. https://doi.org/10.1016/j.jvs.2005.11.002. PMid:16476588.

7 Polok K, Biccard BM, Chan MTV, et al. Mortality and major postoperative complications within 1 year after vascular surgery: a prospective cohort study. Pol Arch Intern Med. 2024;134(2):16645. https://doi.org/10.20452/pamw.16645. PMid:38164648.

8 National Vascular Registry. State of the Nation Report 2023. Results for patients who had vascular procedures during 2022 in NHS hospitals in England, Wales, Scotland and Northern Ireland. London: NVR; 2023 [citado 2025 set 2]. https://www.hqip.org.uk/wp-content/uploads/2023/11/REF-398-NVR-2023-SotN-Report-FINAL.pdf

9 Sarac TP, Bannazadeh M, Rowan AF, et al. Comparative predictors of mortality for endovascular and open repair of ruptured infrarenal abdominal aortic aneurysms. Ann Vasc Surg. 2011;25(4):461-8. https://doi.org/10.1016/j.avsg.2010.12.030. PMid:21549913.

10 Dunkelgrun M, Welten GM, Goei D, et al. Association between serum uric acid and perioperative and late cardiovascular outcome in patients with suspected or definite coronary artery disease undergoing elective vascular surgery. Am J Cardiol. 2008;102(7):797-801. https://doi.org/10.1016/j.amjcard.2008.05.019. PMid:18805100.

11 Tsialtas D, Bolognesi MG, Assimopoulos S, Azzarone M, Volpi R, Bolognesi R. Perioperative complications after major vascular surgery: correlations with preoperative clinical, electrocardiographic and echocardiographic characteristics. Acta Biomed. 2022;93(3):e2022255. PMid:35775755.

12 Scali S, Bertges D, Neal D, et al. Heart rate variables in the Vascular Quality Initiative are not reliable predictors of adverse cardiac outcomes or mortality after major elective vascular surgery. J Vasc Surg. 2015;62(3):710-20.e9. https://doi.org/10.1016/j.jvs.2015.03.071. PMid:26067200.

13 Smeili LAA, Lotufo PA. Incidence and predictors of cardiovascular complications and death after vascular surgery. Arq Bras Cardiol. 2015;105(5):510-8. https://doi.org/10.5935/abc.20150113. PMid:26421535.

14 Genovese EA, Fish L, Chaer RA, Makaroun MS, Baril DT. Risk stratification for the development of respiratory adverse events following vascular surgery using the Society of Vascular Surgery’s Vascular Quality Initiative. J Vasc Surg. 2017;65(2):459-70. https://doi.org/10.1016/j.jvs.2016.07.119. PMid:27832989.

15 van Waes JAR, Nathoe HM, de Graaff JC, et al. Myocardial injury after noncardiac surgery and its association with short-term mortality. Circulation. 2013;127(23):2264-71. https://doi.org/10.1161/CIRCULATIONAHA.113.002128. PMid:23667270.

16 Genovese EA, Fish L, Chaer RA, Makaroun MS, Baril DT. Risk stratification for the development of respiratory adverse events following vascular surgery using the Society of Vascular Surgery’s Vascular Quality Initiative. J Vasc Surg. 2017;65(2):459-70. https://doi.org/10.1016/j.jvs.2016.07.119. PMid:27832989.

17 Wallaert JB, Nolan BW, Adams J, et al. The impact of diabetes on postoperative outcomes following lower-extremity bypass surgery. J Vasc Surg. 2012;56(5):1317-23. https://doi.org/10.1016/j.jvs.2012.04.011. PMid:22819754.

18 Stather PW, Sidloff D, Dattani N, Choke E, Bown MJ, Sayers RD. Systematic review and meta-analysis of the early and late outcomes of open and endovascular repair of abdominal aortic aneurysm. Br J Surg. 2013;100(7):863-72. https://doi.org/10.1002/bjs.9101. PMid:23475697.

19 Schermerhorn ML, O’Malley JA, Jhaveri A, Cotterill P, Pomposelli F, Landon BE. Endovascular vs Open Repair of Abdominal Aortic Aneurisms in the Medicare population. N Engl J Med. 2008;358(5):464-74. https://doi.org/10.1056/NEJMoa0707348. PMid:18234751.

20 Cronenwett JL, Likosky DS, Russell MT, Eldrup-Jorgensen J, Stanley AC, Nolan BW. A regional registry for quality assurance and improvement: The Vascular Study Group of Northern New England (VSGNNE). J Vasc Surg. 2007;46(6):1093-102, discussion 1101-2. https://doi.org/10.1016/j.jvs.2007.08.012. PMid:17950568.

21 Eagle KA, Berger PB, Calkins H, et al. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery – Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation. 2002;105(10):1257-67. https://doi.org/10.1161/circ.105.10.1257. PMid:11889023.

22 American Society of Anesthesiologists. ASA physical status classification system [Internet]. Schaumburg: ASA; 2020 [atualizado dez 2020; citado 2025 set 2]. https://www.asahq.org/standards-and-practice-parameters/statement-on-asa-physical-status-classification-system

23 Wu TY, Anderson NE, Barber PA. Neurological complications of carotid revascularization. J Neurol Neurosurg Psychiatry. 2012;83(5):543-50. https://doi.org/10.1136/jnnp-2011-301162. PMid:22193563.

24 Ferrer C, Cao P, De Rango P, et al. A propensity-matched comparison for endovascular and open repair of thoracoabdominal aortic aneurysms. J Vasc Surg. 2016;63(5):1201-7. https://doi.org/10.1016/j.jvs.2015.10.099. PMid:26776896.

25 Sharifpour M, Moore LE, Shanks AM, Didier TJ, Kheterpal S, Mashour GA. Incidence, predictors, and outcomes of perioperative stroke in noncarotid major vascular surgery. Anesth Analg. 2013;116(2):424-34. https://doi.org/10.1213/ANE.0b013e31826a1a32. PMid:23115255.

26 Stoneham MD, Thompson JP. Arterial pressure management and carotid endarterectomy. Br J Anaesth. 2009;102(4):442-52. https://doi.org/10.1093/bja/aep012. PMid:19233880.

27 Bertges DJ, Goodney PP, Zhao Y, et al. The Vascular Study Group of New England Cardiac Risk Index (VSG-CRI) predicts cardiac complications more accurately than the Revised Cardiac Risk Index in vascular surgery patients. J Vasc Surg. 2010 Sep;52(3):674-83.E3. https://doi.org/10.1016/j.jvs.2010.03.031.

28 Kim JY, Boyle L, Khashram M, Campbell D. Editor’s Choice - Development and Validation of a Multivariable Prediction Model of Peri-operative Mortality in Vascular Surgery: The New Zealand Vascular Surgical Risk Tool (NZRISK-VASC). Eur J Vasc Endovasc Surg. 2021;61(4):657-63. https://doi.org/10.1016/j.ejvs.2020.12.008. PMid:33423913.

29 Bertges DJ, Neal D, Schanzer A, et al. The Vascular Quality Initiative Cardiac Risk Index for prediction of myocardial infarction after vascular surgery. J Vasc Surg. 2016;64(5):1411-1421.e4. https://doi.org/10.1016/j.jvs.2016.04.045. PMid:27449347.

30 Eslami MH, Saadeddin Z, Farber A, Fish L, Avgerinos ED, Makaroun MS. External validation of the Vascular Study Group of New England carotid endarterectomy risk predictive model using an independent U.S. national surgical database. J Vasc Surg. 2020;71(6):1954-63. https://doi.org/10.1016/j.jvs.2019.04.495. PMid:31676184.

31 Allou N, Allyn J, Provenchere S, et al. Clinical utility of a deep-learning mortality prediction model for cardiac surgery decision making. J Thorac Cardiovasc Surg. 2023;166(6):e567-78. https://doi.org/10.1016/j.jtcvs.2023.01.022. PMid:36858843.

32 Fan Y, Dong J, Wu Y, et al. Development of machine learning models for mortality risk prediction after cardiac surgery. Cardiovasc Diagn Ther. 2022;12(1):12-23. https://doi.org/10.21037/cdt-21-648. PMid:35282663.

33 Gupta PK, Ramanan B, Lynch TG, et al. Development and validation of a risk calculator for prediction of mortality after infrainguinal bypass surgery. J Vasc Surg. 2012;56(2):372-9. https://doi.org/10.1016/j.jvs.2012.01.042. PMid:22632800.

34 Li R, Sidawy A, Nguyen BN. Development and Validation of a 30-Day Point-Scoring Risk Calculator for Open Groin Vascular Surgery: The George Washington Groin Score. J Surg Res. 2024;303:295-304. https://doi.org/10.1016/j.jss.2024.09.008. PMid:39393117.

35 Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143(1):29-36. https://doi.org/10.1148/radiology.143.1.7063747. PMid:7063747.

36 Youden WJ. Index for rating diagnostic tests. Cancer. 1950;3(1):32-5. https://doi.org/10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3. PMid:15405679.

37 Gualandro DM, Fornari LS, Caramelli B, et al. Diretriz de Avaliação Cardiovascular Perioperatória da Sociedade Brasileira de Cardiologia – 2024. Arq Bras Cardiol. 2024;121(9):e20240590. PMid:39442131.

38 Moraes-Silva MA, Jesus-Silva SG, Oliveira VR, et al. Fatores de risco associados e sobrevida em curto e médio prazo de pacientes submetidos a correção aberta e endovascular de aneurisma de aorta abdominal. J Vasc Bras. 2018;17(3):206-13.

39 Wenzl FA, Miljkovic SS, Dabestani PJ, et al. A systematic review and individual patient data meta-analysis of heart failure as a rare complication of traumatic arteriovenous fistulas. J Vasc Surg. 2021;73(3):1087-94.e8. https://doi.org/10.1016/j.jvs.2020.08.138. PMid:33002586.

40 Vegni R, Almeida GF, Braga F, et al. Complicações após cirurgia de revascularização miocárdica em pacientes idosos. Rev Bras Ter Intensiva. 2008;20(4):379-84. https://doi.org/10.1590/S0103-507X2008000300004.

41 Hayajneh AA, Hweidi IM, Zytoon AM. Predictors of surgical site infections among patients with diabetes mellitus post coronary artery bypass graft surgery: a quasi-experimental study. Wounds. 2020;32(9):237-43. https://doi.org/10.25270/wnds.2020.07.14. PMid:33166268.

42 Baty M, Chimoriya R, James S, et al. Diabetes in peripheral artery disease: prevalence, complications, and polypharmacy. J Clin Med. 2025;14(4):1383. https://doi.org/10.3390/jcm14041383. PMid:40004919.

43 Zhang X, Hou A, Cao J, et al. Association of diabetes mellitus with postoperative complications and mortality after non-cardiac surgery: a meta-analysis and systematic review. Front Endocrinol (Lausanne). 2022;13:841256. https://doi.org/10.3389/fendo.2022.841256. PMid:35721703.

44 Huber M, Ozrazgat-Baslanti T, Thottakkara P, et al. Mortality and Cost of Acute and Chronic Kidney Disease after Vascular Surgery. Ann Vasc Surg. 2016 Jan;30:72-81.E2. https://doi.org/10.1016/j.avsg.2015.04.092.

45 Pizano A, Scott CK, Porras-Colon J, et al. Chronic kidney disease impacts outcomes after abdominal aortic aneurysm repair. J Vasc Surg. 2023;77(2):415-423.e1. https://doi.org/10.1016/j.jvs.2022.09.003. PMid:36100032.

46 Caron E, Yadavalli SD, Manchella M, et al. Impact of chronic kidney disease on outcomes following vascular procedure in the vascular quality initiative. Ann Surg. 2024;283(2):335-44. https://doi.org/10.1097/SLA.0000000000006520. PMid:39229713.

47 Patel RJ, Zarrintan S, Jagadeesh V, Vootukuru NR, Gaffey A, Malas MB. Long-term outcomes after lower extremity bypass in the actively smoking claudicant. J Vasc Surg. 2023;78(4):1003-11. https://doi.org/10.1016/j.jvs.2023.05.047. PMid:37327952.

48 Vu JV, Lussiez A. Smoking cessation for preoperative optimization. Clin Colon Rectal Surg. 2023;36(3):175-83. https://doi.org/10.1055/s-0043-1760870. PMid:37113283.

49 Cheng H, Clymer JW, Po-Han Chen B, et al. Prolonged operative duration is associated with complications: a systematic review and meta-analysis. J Surg Res. 2018;229:134-44. https://doi.org/10.1016/j.jss.2018.03.022. PMid:29936980.

50 Polo TCF, Miot HA. Aplicações da curva ROC em estudos clínicos e experimentais. J Vasc Bras. 2020;19:e20200186. https://doi.org/10.1590/1677-5449.200186. PMid:34211533.
 


Submetido em:
30/09/2025

Aceito em:
29/01/2026

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