Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/S1677-54492005000400012
Jornal Vascular Brasileiro
Review Article

Bone marrow stem cells and their role in angiogenesis

Paulo Eduardo Ocke Reis

Downloads: 0
Views: 1125

Abstract

The degree of symptomatology of a patient with peripheral arterial disease dictates the kind of treatment. Despite the known therapies, some patients continue to have pain with ambulation, which affects their quality of life. The therapeutic implications of the angiogenic growth factors were identified by the pioneering studies of Folkman et al. 2 decades ago. Further investigations established the possibility of the use of formulations of recombinant angiogenic growth factors, with the objective of developing or increasing the network of collaterals in animal models of chronic myocardial or limb ischemia. Researches suggest that primitive stem cells with whole bone marrow possess greater functional plasticity, capable of contributing to regeneration of ischemic limb muscle and vascular endothelium by adult stem cells. Local autologous marrow stromal cells implantation induces a neovascular response resulting in a significant increase in blood flow to the ischemic limb. In this article we review the studies that have established how the implantation of bone marrow cells into ischemic limbs increases collateral vessel formation.

Keywords

growth factor, angiogenesis factor, stem cells, ischemia

References

Blauw GJ, Lagaay AM, Smelt AH. Stroke, statins and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke. 1997;28:946-50.

Dormandy J, Heeck L, Vig S. Predictors of early disease in the lower limbs. Semin Vasc Surg. 1997;12:109-17.

Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182-6.

Takeshita S, Zheng LP, Brogi E. Therapeutic angiogenesis: A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest. 1994;93:662-70.

Isner JM, Pieczek A, Schainfeld R. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet. 1996;348:370-4.

Murohara T, Asahara T, Silver M. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest. 1998;101:2567-7.

Asahara T, Murohara T, Sullivan A. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-7.

Shi Q, Rafii S, Hong-De Wu. Evidence for circulating bone marrow-derived endothelial cells. Blood. 1998;92:362-7.

Bhattacharya V, Peter A, Shi Q. Enhanced endothelialization and microvessel formation in polyester grafts seeded with CD34+ bone marrow cells. Blood. 2000;95:581-5.

Asahara T, Masuda H, Takahashi T. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85:221-8.

Ikenaga S, Hamano K, Nishida M. Autologous bone marrow implantation induced angiogenesis and improved deteriorated exercise capacity in a rat ischemic hindlimb model. J Surg Res. 2001;96:277-83.

Hirata K, Li TS, Nishida M. Autologous bone marrow cell implantation as therapeutic angiogenesis for ischemic hindlimb in diabetic rat model. Am J Physiol Heart Circ Physiol. 2003;284:H 66-70.

Losordo DW, Vale PR, Hendel RC. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation. 2002;105:2012-18.

Buschmann I, Schaper W. The pathophysiology of the collateral circulation (arteriogenesis). J Pathol. ;190:338-42.

Kalka C, Tehrani H, Laudenberg B. VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease. Ann Thorac Surg. 2000;70:829-34.

Hamano K, Li TS, Kobayashi T. Therapeutic angiogenesis induced by local autologous bone marrow cell implantation. Ann Thorac Surg. 2002;73:1210-5.

Grines CL, Watkins MW, Helmer G. Angiogenic Gene Therapy (AGENT) Trial in patients with stable angina pectoris. Circulation. 2002;105:1291-7.

Heeschen C, Lehmann R, Honold J. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation. 2004;109:1615-22.

Lederman R, Tenaglia A, Anderson R. Design of the therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (TRAFFIC) trial. AJC. 2001;88:192-5.

Iba O, Hiroaki M, Yoshihisa N. Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic lim. Circulation. 2002;106:2019-25.

Al-Khaldi A, Al-Sabti H, Galipeau J. Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model. Ann Thorac Surg. 2003;75:204-9.

Kinnaird T, Stabile E, Burnett MS. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis though paracrine mechanisms. Circ Res. 2004;94:678-85.

Tateishi-Yuyama E, Matsubara H, Murohara T. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone marrow cell: a pilot study and a randomised controlled trial. Lancet. 2002;360:427-35.

Kinnaird T, Stabile E, Burnett MS. Local delivery of marrow-derived stromal cells augments collateral perfusion though paracrine mechanisms. Circulation. 2004;109:1543-9.

Assmus B, Schächinger V, Teupe C. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation. 2002;106:r23-61.

Perin EC, Dohmann HF, Borojevic R. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation. 2003;107:2294-302.

Baumgartner I, Pieczek A, Manor O. Constitutive expression of ph VEGF 165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation. 1998;97:1114-23.

Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)"> Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)">
5ddfe0f50e8825a7384ce1d6 jvb Articles
Links & Downloads

J Vasc Bras

Share this page
Page Sections