Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/S1677-54492009000400005
Jornal Vascular Brasileiro
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Técnica para quantificação e qualificação de material coletado em filtros de proteção cerebral

Gabriel Santos Novaes; Álvaro Razuk Filho; Geanete Pozzan; Andrea Reis; Alexandre Fioranelli; Valter Castelli Jr.; Walter Khegan Karakhanian; Roberto Augusto Caffaro

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Resumo

Contexto: A qualidade e a quantidade de partículas coletadas em filtros de proteção cerebral (FPC) durante angioplastia transluminal percutânea com stent (ATPS) podem esclarecer a importância desses dispositivos no tratamento de estenoses carotídeas. Objetivos: Analisar o conteúdo retido por FPC em pacientes submetidos a ATPS de artéria carótida interna com nova técnica de análise qualiquantitativa. Métodos: O material coletado em 10 FPC durante ATPS da bifurcação da carótida em pacientes com alto risco cirúrgico foi submetido a análise microscópica qualiquantitativa. Fotografias digitais das lâminas com material corado com hematoxilina e eosina foram analisadas com o programa Axio Vision LE Release 4.1, que calculou a área das partículas em micrômetros/metro quadrado (µm²). Resultados: O exame histopatológico evidenciou material em 100% dos filtros consistindo predominantemente de restos hemáticos, cristais de colesterol e cálcio. A área média de fragmentos coletados foi expressiva (1.570.310 µm²), e houve ampla variância desses valores. Conclusões: Os FPC coletam quantidade importante de fragmentos de placas de ateroma, e a grande variância nas quantidades de material coletado pode estar associada com a gravidade da lesão, motivo pelo qual se tornam relevantes estudos que utilizem técnica padronizada para a quantificação desses fragmentos e para a compreensão de seu real significado clínico.

Palavras-chave

Artéria carótida, estenose carotídea, angioplastia transluminal percutânea com stent, filtros de proteção cerebral

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