Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/S1677-54492011000200007
Jornal Vascular Brasileiro
Original Article

Association of lipids with coronary heart disease in a saudi population

Associação de lípidos com doença cardíaca coronariana em população saudita

Mohmed Elfatih Ashmaig; Khalifa Ashmeik; Atif Ahmed; Samia Sobki; Muheeb Abdulla

http://dx.doi.org/10.1590/S1677-54492011000200007 J Vasc Bras, vol.10, n2, p.131-136, 2011
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Abstract

BACKGROUND: The Saudi population is known to have an unhealthy diet in addition to physical inactivity. OBJECTIVE: To investigate the lipid-mediated risk factors that might be associated with increased incidence of coronary heart diseasein the Saudi population as this was found in Western populations. MATERIALS AND METHODS: Two hundred and twenty subjects suspected of having coronary heart disease underwent coronary angiography and blood draw following a 12-hour fast. Total and HDL cholesterol, triglycerides, Lp(a) and lipoprotein lipase were measured by standard methods. Small, dense LDL was measured by the iodixanol method with an ultracentrifugation of only 2.5 hours. RESULTS: One hundred and forty subjects were found to be positive for coronary heart disease while 80 subjects were shown to be negative for this disease. Statistically significant risk factors for coronary heart disease in the Saudi population were hypertriglyceridemia (1.93±0.95 versus1.45±0.16 mmol/L;p<0.0001); low HDL cholesterol (1.09±0.55 vs 1.33±0.63 mmol/L, p=0.0001); high Lp(a) (46.8±45.58 versus 29.06±17.03 mg/dL;p=0.019); and the presence of small, dense LDL (1.0314±0.0028 versus 1.0300±0.0003 g/kg;p=0.0099). Total cholesterol (4.99±1.11 versus 4.75±1.11 mmol/L;p=0.099), LPL (35.56±26.6 versus 27.89±11.96 IU/L;p<0.059), and LDL cholesterol (3.06±1.12 versus 2.79±1.08 mmol/L;p=0.08) were not found to be statistically significant coronary heart disease risk factors. CONCLUSIONS: This study indicates that high TG, low HDL, high Lp(a) and the presence of small, dense LDL may contribute to the incidence of coronary heart disease and that TC was not significantly associated with incidence of coronary heart disease in the Saudi population.

Keywords

Coronary disease, triglycerides, cholesterol, HDL, LDL, lipoproteins

Resumo

CONTEXTO: A população saudita é conhecida por apresentar dietas não saudáveis, além de inatividade física. OBJETIVO: Investigar os lipídeos como fatores de risco que podem associar-se com o aumento da incidência de doença cardíaca coronariana na população saudita, uma vez que isso foi encontrado na população ocidental. MATERIAIS E MÉTODOS: Duzentos e vinte indivíduos com suspeita de doença cardíaca coronariana submeteram-se a angiografia coronária e coleta de sangue, após jejum de 12 horas. Colesterol total e HDL, triglicerídeos, Lp(a) e lipase lipoproteica foram calculados por métodos padrão. LDL pequena e densa foi medida pelo método do iodixanol com ultracentrifugação por apenas 2,5 horas. RESULTADOS: Cento e quarenta indivíduos apresentaram resultado positivo para doença cardíaca coronariana, enquanto 80 pacientes mostraram resultado negativo. Os fatores de risco estatisticamente significantes para doença cardíaca coronariana na população saudita foram hipertrigliceridemia (1,93±0,95 versus 1,45±0,16 mmol/L; p<0,0001); baixo colesterol HDL (1,09±0,55 versus 1,33±0,63 mmol/L; p=0,0001); Lp(a) elevada (46,8±45,58 versus 29,06±17,03 mg/dL; p=0,019) e a presença de LDL pequena e densa (1,0314±0,0028 versus 1,0300±0,0003 g/kg; p=0,0099). Colesterol total (4,99±1,11 versus 4,75±1,11 mmol/L; p=0,099), colesterol LPL (35,56±26,6 versus 27,89±11,96 IU/L; p<0,059) e LDL (3,06±1,12 versus 2,79±1,08 mmol/L; p=0,08) não foram fatores de risco estatisticamente significantes para doença cardíaca coronariana. CONCLUSÕES: Este estudo indica que elevados triglicerídeos, baixo HDL, elevada Lp(a) e a presença de LDL pequena e densa podem contribuir para a incidência de doença cardíaca coronariana. O colesterol total não foi significantemente associado à incidência de doença cardíaca coronariana na população saudita.

Palavras-chave

Doença das coronárias, triglicerídeos, colesterol HDL, lipoproteínas LDL, lipoproteínas

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