Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/1677-5449.008915
Jornal Vascular Brasileiro
Original Article

Experimental model for the study of retrograde flow

Modelo experimental para estudo da circulação retrógrada

Cesar Roberto Busato; Carlos Alberto Lima Utrabo; Leandro Cavalcante Lipinski; Mario Rodrigues Montemór Netto; Eduardo de Souza Tolentino; Fernanda Aparecida de Oliveira Busato Nascimento; Marcio Dias Guilherme Filho

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Abstract

Abstract Background Venous arterialization has been adopted as a strategy for salvage of limbs in critical ischemia without the distal arterial bed, with successful outcomes, but the mechanisms by which irrigation of the extremities takes place are still unknown. Objectives To develop an experimental model to test hypotheses that could explain the mechanisms of blood supply in venous arterialization. Methods Eleven pigs underwent a period of hind limb ischemia followed by reperfusion achieved by venous arterialization, after interposition of conduits filled with 10 ml (5 animals – group 1) or 1 ml (6 animals – group 2) of China Ink. After euthanasia, the limbs were amputated and underwent histological analysis. Results Under optical microscopy, ink staining was observed in the arteriolar lumen of six (55%) of the eleven pigs used in the experiment; four (80%) out of five from group 1 and two (33%) out of six from group 2. Conclusions The experimental model was capable of testing the hypothesis. The presence of China Ink in the arteriolar lumen shows that it is possible to supply the arterial vessels by means of venous arterialization.

Keywords

ischemia, arteriovenous fistula, microcirculation

Resumo

Resumo Contexto A arterialização venosa tem sido adotada com bons resultados como estratégia para salvar membros em isquemia crítica sem leito arterial distal. No entanto, os mecanismos pelos quais a irrigação das extremidades ocorre permanecem desconhecidos. Objetivos Desenvolver um modelo experimental para testar hipóteses que podem explicar os mecanismos de nutrição em arterialização venosa. Métodos Onze porcos foram submetidos a um período de isquemia seguida de reperfusão do membro posterior, realizada por arterialização venosa, com interposição de condutos preenchidos com 10 mL (cinco animais - grupo 1) e 1 mL (seis animais - grupo 2) de tinta da China. Após a eutanásia, os membros foram amputados e submetidos a análise histológica. Resultados Na microscopia óptica, o pigmento foi encontrado no lúmen de arteríolas de seis (55%) dos 11 porcos utilizados no experimento; quatro (80%) de cinco animais eram do grupo 1 e dois (33%) de seis animais eram do grupo 2. Conclusões O modelo experimental utilizado foi capaz de testar a hipótese. A presença de tinta da China no lúmen arteriolar mostra que é possível alcançar o vaso arterial por meio de arterialização venosa.

Palavras-chave

isquemia, fístula arteriovenosa, microcirculação

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