Jornal Vascular Brasileiro
https://jvascbras.org/article/doi/10.1590/1677-5449.210122
Jornal Vascular Brasileiro
Case Report

Mycotic aortic aneurysm in a debilitated patient with compromised immunity; beware of Candida!

Aneurisma micótico da aorta em paciente debilitado com imunidade comprometida – um alerta para Cândida

Thilina Gunawardena; Manujaya Godakandage; Sachith Abeywickrama; Rezni Cassim; Mandika Wijeyaratne

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Abstract

Abstract: Candida is a rare cause of infected aortic aneurysms. We report the case of a diabetic patient with end stage kidney disease who underwent repair of a leaking abdominal aortic aneurysm. He was on long-term antibiotic treatment for malignant otitis externa. Candida albicans was isolated from the culture of the excised aneurysm wall. An infected aortic aneurysm due to Candida has not been previously reported in a patient with malignant otitis externa. This case report aims to highlight that Candida should be suspected as a cause of infected aortic aneurysms in patients with debilitation and chronic immunosuppression. Management of such cases can be extremely challenging, especially in resource-poor settings, and we will be touching upon the advantages and disadvantages of various treatment options.

Keywords

malignant otitis externa, candida, mycotic aneurysm, in situ repair

Resumo

Resumo: A cândida é uma causa rara de aneurismas da aorta infecciosos. Relatamos o caso de um paciente diabético com doença renal terminal, que foi submetido a reparo de aneurisma da aorta abdominal com vazamento. Ele estava em tratamento de longo prazo com antibióticos para otite externa maligna. A Candida albicans foi isolada da cultura da parede do aneurisma que sofreu a excisão. Não há relatos prévios de aneurisma da aorta infeccioso causado por cândida em pacientes com otite externa maligna. Este relato de caso visa reforçar que a cândida deve ser uma das suspeitas de causa de aneurisma da aorta infeccioso em pacientes debilitados e com imunossupressão crônica. O manejo desses casos pode ser extremamente desafiador, principalmente em contextos em que os recursos são escassos, e mencionaremos as vantagens e desvantagens das diversas opções de tratamento.
 

Palavras-chave

otite externa maligna, cândida, aneurisma micótico, reparo in situ

References

1 Eggimann P, Que YA, Revelly JP, Pagani JL. Preventing invasive candida infections: where could we do better? J Hosp Infect. 2015;89(4):302-8. http://dx.doi.org/10.1016/j.jhin.2014.11.006. PMid:25592726.

2 Kumar SP, Ravikumar A, Somu L, Ismail NM. Malignant otitis externa: an emerging scourge. Journal of Clinical Gerontology and Geriatrics. 2013;4(4):128-31. http://dx.doi.org/10.1016/j.jcgg.2013.02.003.

3 Cohen D, Friedman P. The diagnostic criteria of malignant external otitis. J Laryngol Otol. 1987;101(3):216-21. http://dx.doi.org/10.1017/S0022215100101562. PMid:3106547.

4 Woodrum DT, Welke KF, Fillinger MF. Candida infection associated with a solitary mycotic common iliac artery aneurysm. J Vasc Surg. 2001;34(1):166-8. http://dx.doi.org/10.1067/mva.2001.115381. PMid:11436091.

5 Barry MC, Jackson N, Adeboysku D, Tran T, McNeil I, Grace PA. Candida albicans mycotic abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 1997;13(2):237-9. http://dx.doi.org/10.1016/S1078-5884(97)80028-7. PMid:9091164.

6 Kretz B, Pagès PB, Loffroy R, et al. Mycotic aneurysm of both internal iliac arteries due to Candida albicans. Ann Vasc Surg. 2014;28(3):738.e11-4. http://dx.doi.org/10.1016/j.avsg.2013.06.022. PMid:24360942.

7 Ikeda M, Kambayashi J, Kawasaki T. Contained rupture of infected abdominal aortic aneurysm due to systemic candidiasis. Cardiovasc Surg. 1995;3(6):711-4. http://dx.doi.org/10.1016/0967-2109(96)82875-4. PMid:8745199.

8 Marty-Ané C, Alric P, Prudhomme M, Picard E, Mary H. Bilateral splenorenal bypass and axillofemoral graft for management of juxtarenal mycotic aneurysm. Cardiovasc Surg. 1996;4(3):331-4. http://dx.doi.org/10.1016/0967-2109(95)00040-2. PMid:8782930.

9 Rubin BG, German ML. Candida infection with aneurysm formation in the juxtarenal aorta. J Vasc Surg. 1994;20(2):311-4. http://dx.doi.org/10.1016/0741-5214(94)90021-3. PMid:8040957.

10 Brown C Jr, Propp S, Guest CM, Beebe RT, Early L. Fatal fungus infections complicating antibiotic therapy. J Am Med Assoc. 1953;152(3):206-7. http://dx.doi.org/10.1001/jama.1953.03690030006002. PMid:13044498.

11 Dubois M, Daenens K, Houthoofd S, Peetermans WE, Fourneau I. Treatment of mycotic aneurysms with involvement of the abdominal aorta: single-centre experience in 44 consecutive cases. Eur J Vasc Endovasc Surg. 2010;40(4):450-6. http://dx.doi.org/10.1016/j.ejvs.2010.07.017. PMid:20719550.

12 Nemoto Y, Hosoi Y, Hoshina K, Nunokawa M, Kubota H, Watanabe T. In Situ Reconstruction with Extended Debridement in Patients with Mycotic Abdominal Aortic Aneurysms. Ann Vasc Dis. 2017;10(2):159-63. http://dx.doi.org/10.3400/avd.hdi.17-00001. PMid:29034046.

13 Fichelle JM, Tabet G, Cormier P, et al. Infected infrarenal aortic aneurysms: when is in situ reconstruction safe? J Vasc Surg. 1993;17(4):635-45. http://dx.doi.org/10.1016/0741-5214(93)90105-U. PMid:8464080.

14 Janko MR, Bose S, Lawrence PF. Current status of treatment for aortic graft infection: when should cryopreserved allografts be used? Semin Vasc Surg. 2019;32(1-2):81-7. http://dx.doi.org/10.1053/j.semvascsurg.2019.07.001. PMid:31540661.

15 Hayes PD, Nasim A, London NJ, et al. In situ replacement of infected aortic grafts with rifampicin-bonded prostheses: the Leicester experience (1992 to 1998). J Vasc Surg. 1999;30(1):92-8. http://dx.doi.org/10.1016/S0741-5214(99)70180-1. PMid:10394158.

16 Kan CD, Lee HL, Yang YJ. Outcome after endovascular stent graft treatment for mycotic aortic aneurysm: a systematic review. J Vasc Surg. 2007;46(5):906-12. http://dx.doi.org/10.1016/j.jvs.2007.07.025. PMid:17905558.

17 Oichi T, Sasaki S, Tajiri Y. Spondylodiscitis concurrent with infectious aortic aneurysm caused by Candida tropicalis: a case report. J Orthop Surg (Hong Kong). 2015;23(2):251-4. http://dx.doi.org/10.1177/230949901502300230. PMid:26321563.
 

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